Keratin is a fibrous protein available in hair, nails, horn, hoofs, wool, hair, feathers and epithelial cells
in the outermost layers of skin. It is subdivided into alpha-keratins and beta-keratins, based on the
structure of polypeptide chains. Keratin can be extracted by several methods viz., chemical hydrolysis,
enzymatic and microbial treatment, dissolution in ionic liquids, microwave process, steam explosion,
and thermal hydrolysis. It is a natural protein polymeric biomaterial and has been used in the fields of
textile fibre, textile finishing & auxiliaries, film, hydrogel, sponges and scaffolds, and cosmetics. The
underutilized coarser and waste wool, and other hair fibres can be used for extraction of keratin, while
addressing the sustainable management of such bio-wastes. Keratin biomaterial has many advantages
over the conventional biomolecules, namely unique chemistry due to its high sulphur content, notable
biocompatibility, propensity for self-assembly, and intrinsic cellular recognition. Keratin polymer-based
biofibres are strong and elastic, and have requisite moisture wicking properties, making them a new class
of material for textile application. Substrates developed using keratin and blends show hypoallergenic and
antimicrobial properties, making them a preferred a choice for clothing and other applications. Properties
of paper produced from the feather fibre and wood pulp were compared with the hand-sheets, made
of 100% wood pulp. This paper reviews the characteristic of keratin biomaterial, its extraction process
and different end applications.